BIOMEDICAL RESEARCH CORES

Tissue morphology and knowledge of the localization of specific proteins within a cell are integral to understanding cellular metabolism, the causes and consequences of diabetes, and new advances for the treatment of diabetes.

The purpose of the Animal Physiology Core is to provide technically advanced physiological evaluation of metabolism in diabetes, obesity, and the associated complications in rodents for Joslin Diabetes Research Center investigators and outside users.

The Core aims to ensure that researchers at Joslin and externally take advantage of the most modern and robust methods available in the field of bioinformatics and biostatistics, including for new data types and novel analysis requests.

The CRISPR screen core aims to help Joslin researchers to take advantage of the cutting-edge whole genome CRISPR screen technology, to do innovative research and discover new targets for your research projects.

The Joslin Flow Cytometry Core provides reliable and affordable cell sorting and flow cytometry services to its users so that they can isolate, analyze, and study cells that increase our understanding of diabetes and its complications, and ultimately, develop treatments and cures for these diseases.

The Genome Editing Core (GEC) provides investigators with resources to manipulate the genome of human cell lines and laboratory mice with the aim of studying the genetics underlying diabetes and its complications.

The objective of the Molecular Phenotyping and Genotyping Core is to support Joslin and external investigators in the study of molecular mechanisms of disease by providing equipment, expertise, and services in molecular phenotyping.