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Molecular Phenotyping and Genotyping Core

Overview of Services

The objective of the Molecular Phenotyping and Genotyping Core is to support Joslin and external investigators in the study of molecular mechanisms of disease by providing equipment, expertise, and services in molecular phenotyping, including nucleic acid sequence analyses, gene expression, and other “-omics” analyses, which would be too specialized or costly for individual laboratories to perform independently. Formerly known as the Advanced Genomics and Genetics Core, the Molecular Phenotyping Core is newly-named in recognition of the expansion of its analytical capacities to reflect not only genetic and genomic analyses but also metabolic phenotyping.

 

Current services

  • DNA Purification

  • DNA repository

  • SNP genotyping

  • Bioanalyzer analysis of DNA/RNA

  • DNA shearing

  • Next Generation Sequencing

  • Genetic Characterization of Diabetes for Clinical Studies

  • Bioenergetics of Cells and Tissues (Seahorse Bioanalyzer)

  • Digital PCR (ddPCR)

  • Real-time qRT-PCR expression analysis

  • Education and training

 

New services!

  • Single Cell Analysis (10X Genomics) 

  • Qiagen Qiacube Connect 

 

 

Publication Disclaimer

If any of your research has been supported in full or in part by a Joslin Diabetes Center DRC Core, please acknowledge the NIH/NIDDK grant as follows: "Supported by DRC, Grant No. P30 DK036836."

Location and hours of operation

Hours Location

Monday - Friday
8AM - 5PM 

1 Joslin Place
Boston, MA. 02215

Links and Resources

  1. Molecular Phenotyping Genotyping Core

Contacts

Name Role Phone Email Location
Alessandro Doria and Mary-Elizabeth Patti
Co-Directors (genetics/genomics)
 
617-309-1966 / 617-309-2635
 
alessandro.doria@joslin.harvard.edu / MaryElizabeth.Patti@joslin.harvard.edu
 
Room 445A / Room 620
 
Christine Mendonca
Core Manager (genetics)
 
617-309-2735
 
christine.mendonca@joslin.harvard.edu
 
Room 445E
 
Alyssa Suarez
Research assistant (genetics)
 
617-309-4590
 
alyssa.suarez@joslin.harvard.edu
 
Room 467
 
Qiong Zhou
Core Manager (genomics)
 
617-309-4794
 
Qiong.Zhou@joslin.harvard.edu
 
Room 607